Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides† †Electronic supplementary information (ESI) available: Full experimental details, 1H, 13C and 31P spectra of all new compounds, HPLC charts, ESI-MS spectra of all new ODNs and representative UV melting data. See DOI: 10.1039/c7sc04318j

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition† †Electronic supplementary information (ESI) available: Full experimental details and copies of 1H, 13C, 31P NMR spectra for all compounds. See DOI: 10.1039/c6ob00007j Click here for additional data file.

Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.

Dynamic induction of enantiomeric excess from a prochiral azobenzene dimer under circularly polarized light† †Electronic supplementary information (ESI) available: Synthesis, 1H NMR spectra, 13C NMR spectra, UV absorption plots, HPLC traces, and CD spectra of the compounds; crystallographic information files. CCDC 1003754. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc01993h Click here for additional data file. Click here for additional data file.

Copper-catalyzed direct alkylation of heteroarenes† †Electronic supplementary information (ESI) available: Experimental procedures, characterization and copies of 1H and 13C NMR spectra for all new compounds. See DOI: 10.1039/c6sc05622a Click here for additional data file.

Gold(iii)–arene complexes by insertion of olefins into gold–aryl bonds† †Electronic supplementary information (ESI) available: Experimental details (syntheses, analytical data and copies of 1H, 13C and 31P NMR spectra), crystallographic data of 2 and computational details. CCDC 1526613 and 1538015. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00145b Click here for additional data file. Click here for additional data file.

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction† †Electronic supplementary information (ESI) available: Full experimental details, 1H and 13C NMR spectra and X-ray crystallographic data for compound 4d. CCDC 936207. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02547d Click here for additional data file. Click here for additional data file.